An article on the identification of phospholipids relevant to cancer tissue using DMS has been published in the International Journal of Molecular Sciences! Identification of three cancer-relevant phospholipids, phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE) was studied.

As a step forward from our previous study of lecithin, this time individual phospholipids were used. The sampling was also more reminiscent of intraoperative use than in the previous study. Phospholipids were mixed bovine skeletal muscle in concentrations of 2.5 mg/g to 10 mg/g. PC was used to study the detection threshold, and all three phospholipids were used to test the differentiating capabilities of the method. The sampling was performed with a monopolar surgical blade.

The study found that PC can be detected with reliable accuracy in concentrations above 5 mg/g. PI and PE were not detectable with statistically significant reliability even with higher (10 mg) increments.

You can read the open access article here!