Method for the Intraoperative Detection of IDH Mutation in Gliomas with DMS

Olfactomics IonVision was used to assess the prognostically significant IDH mutation status in various central nervous system malignanies by Tampere University and Tampere University Hospital researchers. The Open access article is now out!

11 IDH-mutated and 11 IDH wild-type tumors were obtained prospectively, and cut into 88 smaller specimen. The specimen were sampled with a carbon dioxide laser, and the resulting smoke was analyzed with the IonVision DMS system. An LDA algorithm was used to classify the tumors with 88 % classification accuracy. The results show that DMS is capable of differentiating between IDH-mutated and IDH wild-type tumors in a setting suitable for intraoperative use.

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